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TRAF2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13857c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13857c-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
TRAF2 Antibody (Center) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q12933 |
| Other Accession | NP_066961.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 55859 Da |
TRAF2 Antibody (Center) - Additional info | |
| Gene ID 7186 | |
| Other Names TRAF2; TRAP3; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3 | |
| Target/Specificity This TRAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-207 amino acids from the Central region of human TRAF2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TRAF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TRAF2 Antibody (Center) - Protein Information | |
| Name TRAF2 | |
| Synonyms TRAP3 | |
| Function Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis Required for normal antibody isotype switching from IgM to IgG Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain | |
| Cellular Location Cytoplasm. | |
TRAF2 Antibody (Center) - Related products
AM1895a: TRAF2 antibody ( Ascites)
AP13857c: TRAF2 Antibody (Center)
AP7825b: TRAF2 Antibody (C-term)
AP7825c: TRAF2 Antibody (Center)
RI15437: TRAF2 predesign siRNA
DC06383: Human TRAF2 cDNA Clone
LY11558a: TRAF2 Over-expression Lysate
BP7825b: TRAF2 Antibody (C-term) Blocking Peptide
TRAF2 Antibody (Center) - Application data
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TRAF2 Antibody (Center) (Cat. #AP13857c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TRAF2 antibody detected the TRAF2 protein (arrow).
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Western blot analysis of TRAF2 (arrow) using rabbit polyclonal TRAF2 Antibody (Center) (Cat. #AP13857c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TRAF2 gene.
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TRAF2 Antibody (Center) (Cat. #AP13857c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRAF2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
TRAF2 Antibody (Center) - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Song, Y.J., et al. Virus Genes 41(2):174-180(2010) Mace, P.D., et al. J. Mol. Biol. 400(1):8-15(2010) Alvarez, S.E., et al. Nature 465(7301):1084-1088(2010) Zhang, W., et al. Chin. Med. Sci. J. 25(1):1-12(2010)
