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RLN1/RLN2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P04808 |
| Other Accession | P04090, NP_008842.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21146 Da |
| Antigen Region | 136-165 aa |
| Gene ID | 6013 |
|---|---|
| Other Names | Prorelaxin H1, Relaxin B chain, Relaxin A chain, RLN1 |
| Target/Specificity | This RLN1/RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the C-terminal region of human RLN1/RLN2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RLN1/RLN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RLN1 |
|---|---|
| Function | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. |
| Cellular Location | Secreted. |
| Tissue Location | Prostate. Not expressed in placenta, decidua or ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet. [provided by RefSeq].
References
Radestock, Y., et al. Mol. Cancer Res. 8(4):494-506(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Ferlin, A., et al. Bone 46(2):504-513(2010)
Vogel, I., et al. In Vivo 23(6):1005-1009(2009)
Anumba, D.O., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 147(1):41-45(2009)
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