|Application ||WB, IHC-P, E|
|Other Accession||Q5ZL74, Q17QI5, NP_001138621.1, NP_005629.1, NP_001172112.1|
|Calculated MW||24935 Da|
|Antigen Region||51-80 aa|
|Other Names||Vesicle-associated membrane protein 7, VAMP-7, Synaptobrevin-like protein 1, Tetanus-insensitive VAMP, Ti-VAMP, VAMP7, SYBL1|
|Target/Specificity||This VAMP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the Central region of human VAMP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAMP7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein Cell junction, synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).|
|Tissue Location||Detected in all tissues tested.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.
Vivona, S., et al. J. Biol. Chem. 285(23):17965-17973(2010)
Danglot, L., et al. J. Cell. Sci. 123 (PT 5), 723-735 (2010) :
Fader, C.M., et al. Biochim. Biophys. Acta 1793(12):1901-1916(2009)
Burgo, A., et al. EMBO Rep. 10(10):1117-1124(2009)
Ward, D.M., et al. Mol. Biol. Cell 11(7):2327-2333(2000)
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