|Application ||WB, IHC-P, E|
|Calculated MW||84423 Da|
|Antigen Region||409-438 aa|
|Other Names||Calpain-11, 3422-, Calcium-activated neutral proteinase 11, CANP 11, CAPN11|
|Target/Specificity||This CAPN11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-438 amino acids from the Central region of human CAPN11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPN11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome|
|Tissue Location||Highest expression in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis.
Ben-Aharon, I., et al. Mol. Reprod. Dev. 73(6):767-773(2006)
Dear, T.N., et al. Genomics 59(2):243-247(1999)
Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)
Saido, T.C., et al. FASEB J. 8(11):814-822(1994)
Melloni, E., et al. Trends Neurosci. 12(11):438-444(1989)
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