CAPN11 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9UMQ6 |
Other Accession | NP_008989.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 84423 Da |
Antigen Region | 409-438 aa |
Gene ID | 11131 |
---|---|
Other Names | Calpain-11, 3422-, Calcium-activated neutral proteinase 11, CANP 11, CAPN11 |
Target/Specificity | This CAPN11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-438 amino acids from the Central region of human CAPN11. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CAPN11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CAPN11 |
---|---|
Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome |
Tissue Location | Highest expression in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis.
References
Ben-Aharon, I., et al. Mol. Reprod. Dev. 73(6):767-773(2006)
Dear, T.N., et al. Genomics 59(2):243-247(1999)
Rojas, F.J., et al. Mol. Hum. Reprod. 5(6):520-526(1999)
Saido, T.C., et al. FASEB J. 8(11):814-822(1994)
Melloni, E., et al. Trends Neurosci. 12(11):438-444(1989)
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