|Application ||WB, E|
|Other Accession||P22462, Q14B80, NP_631874.1, NP_631875.1, NP_715624.1|
|Calculated MW||70226 Da|
|Antigen Region||544-573 aa|
|Other Names||Potassium voltage-gated channel subfamily C member 2, Voltage-gated potassium channel Kv32, KCNC2|
|Target/Specificity||This KCNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-573 amino acids from the C-terminal region of human KCNC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Three transcript variants encoding three different isoforms have been found for this gene.
Wang, Z., et al. J. Gen. Physiol. 133(4):361-374(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Haas, M., et al. Mamm. Genome 4(12):711-715(1993)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.