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KCNC2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNC2 Antibody (C-term) AP13871b
    KCNC2 Antibody (C-term) (Cat. #AP13871b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the KCNC2 antibody detected the KCNC2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96PR1
Other Accession P22462, Q14B80, NP_631874.1, NP_631875.1, NP_715624.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 70226 Da
Antigen Region 544-573 aa
Additional Information
Gene ID 3747
Other Names Potassium voltage-gated channel subfamily C member 2, Voltage-gated potassium channel Kv32, KCNC2
Target/Specificity This KCNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-573 amino acids from the C-terminal region of human KCNC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNC2 (HGNC:6234)
Function Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high- threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation- dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike- evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000250|UniProtKB:Q14B80}; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, axon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q14B80}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Synapse, synaptosome {ECO:0000250|UniProtKB:P22462}. Synapse {ECO:0000250|UniProtKB:P22462} Apical cell membrane {ECO:0000250|UniProtKB:P22462}. Basolateral cell membrane {ECO:0000250|UniProtKB:P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil Localized in starburst cell somata and proximal dendrite processes Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites. {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80}
Research Areas
Citations (0)
citation

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Background

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Three transcript variants encoding three different isoforms have been found for this gene.

References

Wang, Z., et al. J. Gen. Physiol. 133(4):361-374(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Haas, M., et al. Mamm. Genome 4(12):711-715(1993)

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$ 182.50
$ 70.00
Cat# AP13871b
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