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PPM1D Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PPM1D Antibody (Center) AP13875C
    All lanes : Anti-PPM1D Antibody (Center) at 1:1000 dilution Lane 1: ZR-75-1 whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - PPM1D Antibody (Center) AP13875C
    PPM1D Antibody (Center) (Cat. #AP13875c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PPM1D antibody detected the PPM1D protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15297
Other Accession Q9QZ67, NP_003611.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 66675 Da
Antigen Region 183-212 aa
Additional Information
Gene ID 8493
Other Names Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Target/Specificity This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPM1D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1D
Synonyms WIP1
Function Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.


Zhang, X., et al. Cancer Res. 70(18):7176-7186(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Moon, S.H., et al. J. Biol. Chem. 285(17):12935-12947(2010)
Macurek, L., et al. Oncogene 29(15):2281-2291(2010)
Yang, D.H., et al. Zhonghua Yi Xue Za Zhi 90(8):519-522(2010)

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$ 295.00
$ 99.00
Cat# AP13875C
(40 western blots)
Availability: In Stock
Bulk Size
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