|Application ||WB, E|
|Calculated MW||35504 Da|
|Antigen Region||14-43 aa|
|Other Names||Deoxyribonuclease gamma, DNase gamma, 3121-, DNase I homolog protein DHP2, Deoxyribonuclease I-like 3, DNase I-like 3, Liver and spleen DNase, LS-DNase, LSD, DNASE1L3, DHP2, DNAS1L3|
|Target/Specificity||This DNASE1L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human DNASE1L3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNASE1L3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.|
|Cellular Location||Nucleus. Note=May first pass through the ER membrane before being imported in the nucleus|
|Tissue Location||Liver and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ueki, M., et al. Clin. Chim. Acta 407 (1-2), 20-24 (2009) :
Mizuta, R., et al. Biomed. Res. 30(3):165-170(2009)
Boulares, H., et al. Biochem. Biophys. Res. Commun. 341(2):653-662(2006)
Okamoto, M., et al. Biochem. Biophys. Res. Commun. 327(1):76-83(2005)
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