|Application ||WB, IHC-P, E|
|Calculated MW||41868 Da|
|Antigen Region||300-329 aa|
|Other Names||Dual specificity protein phosphatase 9, Mitogen-activated protein kinase phosphatase 4, MAP kinase phosphatase 4, MKP-4, DUSP9, MKP4|
|Target/Specificity||This DUSP9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the C-terminal region of human DUSP9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inactivates MAP kinases. Has a specificity for the ERK family.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq].
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)
Liu, Y., et al. Cancer Res. 67(22):10711-10719(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Muda, M., et al. J. Biol. Chem. 272(8):5141-5151(1997)
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