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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NFATC1 Antibody (C-term)   

NFATC1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NFATC1 Antibody (C-term) AP13900b
    NFATC1 Antibody (C-term) (Cat. #AP13900b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NFATC1 antibody detected the NFATC1 protein (arrow).
  • IHC-P - NFATC1 Antibody (C-term) AP13900b
    NFATC1 Antibody (C-term) (AP13900b)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NFATC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95644
Other Accession NP_765977.1, NP_765978.1, NP_765975.1, NP_006153.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 101243 Da
Antigen Region 898-927 aa
Additional Information
Gene ID 4772
Other Names Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC
Target/Specificity This NFATC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human NFATC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNFATC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NFAT2, NFATC
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription
Tissue Location Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.
Research Areas
Citations (0)

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The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.


Liu, Y.J., et al. Obesity (Silver Spring) 18(12):2339-2346(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Chen, C., et al. Biocell 34(2):57-63(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Amaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)

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$ 295.00
$ 99.00
Cat# AP13900b
(40 western blots)
Availability: In Stock
Bulk Size
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