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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Acvr2b Antibody (Center)   

Mouse Acvr2b Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Acvr2b Antibody (Center) AP13908c
    All lanes : Anti-Acvr2b Antibody (Center) at 1:1000 dilution Lane 1: mouse kidney lysate Lane 2: mouse skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 61 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - Mouse Acvr2b Antibody (Center) AP13908c
    All lanes : Anti-Acvr2b Antibody (Center) at 1:1000 dilution Lane 1: mouse kidney lysate Lane 2: mouse skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 61 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - Mouse Acvr2b Antibody (Center) AP13908c
    Mouse Acvr2b Antibody (Center) (Cat. #AP13908c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the Acvr2b antibody detected the Acvr2b protein (arrow).
  • WB - Mouse Acvr2b Antibody (Center) AP13908c
    Mouse Acvr2b Antibody (Center) (Cat. #AP13908c) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Acvr2b antibody detected the Acvr2b protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P27040
Other Accession NP_031423.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60542 Da
Antigen Region 148-176 aa
Additional Information
Gene ID 11481
Other Names Activin receptor type-2B, Activin receptor type IIB, ACTR-IIB, Acvr2b
Target/Specificity This Mouse Acvr2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-176 amino acids from the Central region of mouse Acvr2b.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Acvr2b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Acvr2b
Function Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

References

Natale, D.R., et al. Dev. Biol. 335(1):120-131(2009)
Gamer, L.W., et al. Dev. Dyn. 238(9):2374-2381(2009)
Yamamoto, M., et al. J. Cell Biol. 184(2):323-334(2009)
Morita, S., et al. PLoS ONE 4 (1), E4212 (2009) :
Landry, J., et al. PLoS Genet. 4 (10), E1000241 (2008) :

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Cat# AP13908c
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