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> home > Products > Antibodies > Biological Process > Protein Amino Acid Phosphorylation > Mouse Csf1r Antibody (C-term)
Mouse Csf1r Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP13911b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13911b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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Mouse Csf1r Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P09581 |
| Other Accession | Q00495, NP_001032948.2 |
| Reactivity | Mouse |
| Predicted | Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 109179 Da |
Mouse Csf1r Antibody (C-term) - Additional info | |
| Gene ID 12978 | |
| Other Names Csf1r; Csfmr; Fms; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; Proto-oncogene c-Fms; CD_antigen=CD115; Flags: Precursor | |
| Target/Specificity This Mouse Csf1r antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 894-923 amino acids from the C-terminal region of human Mouse Csf1r. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Mouse Csf1r Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Mouse Csf1r Antibody (C-term) - Protein Information | |
| Name Csf1r | |
| Synonyms Csfmr, Fms | |
| Function Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1 Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2 Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor | |
| Cellular Location Cell membrane; Single-pass type I membrane protein. Note=The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation | |
| Tissue Location Widely expressed. | |
Mouse Csf1r Antibody (C-term) - Related products
Mouse Csf1r Antibody (C-term) - Application data
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Mouse Csf1r Antibody (C-term) (Cat. #AP13911b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Csf1r antibody detected the Csf1r protein (arrow).
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Mouse Csf1r Antibody (C-term) (AP13911b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Csf1r Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Mouse Csf1r Antibody (C-term) - Research Areas
AntibodiesBiological ProcessProtein Amino Acid PhosphorylationPost-translational Protein ModificationPhosphate Metabolic ProcessPhosphorus Metabolic ProcessPhosphorylationProtein Modification ProcessBiopolymer ModificationMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessEnzyme Linked Receptor Protein Signaling PathwayCellular Macromolecule Metabolic ProcessTransmembrane Receptor Protein Tyrosine Kinase Signaling PathwayCellular CompartmentReceptor Complex
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BACKGROUND
Csf1r is a protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.
REFERENCES
Gueller, S., et al. J. Leukoc. Biol. 88(4):699-706(2010) Nagamachi, A., et al. Dev. Biol. 345(2):226-236(2010) Wei, S., et al. J. Leukoc. Biol. 88(3):495-505(2010) Maitra, R., et al. J. Immunol. 185(3):1485-1491(2010) Aikawa, Y., et al. Nat. Med. 16(5):580-585(2010)
