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Mouse Mknk2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8CDB0 |
| Other Accession | Q5U2N4, NP_067437.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51633 Da |
| Antigen Region | 36-64 aa |
| Gene ID | 17347 |
|---|---|
| Other Names | MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2, Mknk2, Mnk2 |
| Target/Specificity | This Mouse Mknk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of mouse Mknk2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Mknk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Mknk2 |
|---|---|
| Synonyms | Mnk2 |
| Function | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A- inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
| Cellular Location | Cytoplasm. Nucleus, PML body |
| Tissue Location | Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mknk2 may play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
References
Ueda, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):13984-13990(2010)
Furic, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14134-14139(2010)
Joshi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12097-12102(2009)
Chrestensen, C.A., et al. Genes Cells 12(10):1133-1140(2007)
Shenberger, J.S., et al. Int. J. Biochem. Cell Biol. 39(10):1828-1842(2007)
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