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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Mknk2 Antibody (N-term)   

Mouse Mknk2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Mknk2 Antibody (N-term) AP13922a
    Mouse Mknk2 Antibody (N-term) (Cat. #AP13922a) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8CDB0
Other Accession Q5U2N4, NP_067437.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51633 Da
Antigen Region 36-64 aa
Additional Information
Gene ID 17347
Other Names MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2, Mknk2, Mnk2
Target/Specificity This Mouse Mknk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of mouse Mknk2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mknk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mknk2
Synonyms Mnk2
Function Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Cellular Location Cytoplasm. Nucleus, PML body
Tissue Location Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain.
Research Areas
Citations (0)

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Mknk2 may play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).


Ueda, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):13984-13990(2010)
Furic, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14134-14139(2010)
Joshi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):12097-12102(2009)
Chrestensen, C.A., et al. Genes Cells 12(10):1133-1140(2007)
Shenberger, J.S., et al. Int. J. Biochem. Cell Biol. 39(10):1828-1842(2007)

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$ 295.00
$ 99.00
Cat# AP13922a
(40 western blots)
Availability: In Stock
Bulk Size
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