|Application ||WB, E|
|Calculated MW||86372 Da|
|Antigen Region||174-203 aa|
|Other Names||Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, Mylk3|
|Target/Specificity||This Mouse Mylk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the N-terminal region of mouse Mylk3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mylk3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Kinase that phosphorylates MYL2 in vitro. Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility.|
|Tissue Location||Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Mylk3 may play a role in smooth muscle contraction (By similarity).
White, R.A., et al. Blood Cells Mol. Dis. 43(2):141-148(2009)
Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)
Kim, B.J., et al. Can. J. Physiol. Pharmacol. 85(12):1254-1262(2007)
Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)
Choi, Y.O., et al. Exp. Mol. Med. 38(2):180-189(2006)
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