|Application ||WB, IHC-P, E|
|Other Accession||Q8AXB4, Q62829, O75914, NP_001181977.1, NP_032804.2|
|Predicted||Human, Rat, Xenopus|
|Calculated MW||62398 Da|
|Antigen Region||124-152 aa|
|Other Names||Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3, Pak3, Pak-3, Pakb, Stk4|
|Target/Specificity||This Mouse Pak3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of mouse Pak3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Pak3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Pak-3, Pakb, Stk4|
|Function||Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601). Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.|
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Provided below are standard protocols that you may find useful for product applications.
Key regulator of synapse formation and plasticity in the hippocampus.
Shimogori, T., et al. Nat. Neurosci. 13(6):767-775(2010)
Jiang, X.S., et al. Hum. Mol. Genet. 19(7):1347-1357(2010)
Demyanenko, G.P., et al. Neuroscience 165(1):107-115(2010)
Grimsley-Myers, C.M., et al. J. Neurosci. 29(50):15859-15869(2009)
Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) :
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