|Application ||WB, IHC-P, E|
|Other Accession||Q8AXB4, Q62829, O75914, NP_001181977.1, NP_032804.2|
|Predicted||Human, Rat, Xenopus|
|Calculated MW||62398 Da|
|Antigen Region||124-152 aa|
|Other Names||Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3, Pak3, Pak-3, Pakb, Stk4|
|Target/Specificity||This Mouse Pak3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of mouse Pak3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Pak3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Pak-3, Pakb, Stk4|
|Function||Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.|
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Provided below are standard protocols that you may find useful for product applications.
Key regulator of synapse formation and plasticity in the hippocampus.
Shimogori, T., et al. Nat. Neurosci. 13(6):767-775(2010)
Jiang, X.S., et al. Hum. Mol. Genet. 19(7):1347-1357(2010)
Demyanenko, G.P., et al. Neuroscience 165(1):107-115(2010)
Grimsley-Myers, C.M., et al. J. Neurosci. 29(50):15859-15869(2009)
Sansom, S.N., et al. PLoS Genet. 5 (6), E1000511 (2009) :
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