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>   home   >   Products   >   Primary Antibodies   >   Mouse Pan3 Antibody (C-term)   

Mouse Pan3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Pan3 Antibody (C-term) AP13932b
    Mouse Pan3 Antibody (C-term) (Cat. #AP13932b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Pan3 antibody detected the Pan3 protein (arrow).
  • WB - Mouse Pan3 Antibody (C-term) AP13932b
    Mouse Pan3 Antibody (C-term) (Cat. #AP13932b) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Pan3 antibody detected the Pan3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q640Q5
Other Accession Q58A45, NP_082567.3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 89745 Da
Antigen Region 727-755 aa
Additional Information
Gene ID 72587
Other Names PAB-dependent poly(A)-specific ribonuclease subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}, PAB1P-dependent poly(A)-nuclease {ECO:0000255|HAMAP-Rule:MF_03181}, PAN deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181}, Pan3
Target/Specificity This Mouse Pan3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 727-755 amino acids from the C-terminal region of mouse Pan3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Pan3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pan3
Function Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.
Cellular Location Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03181, ECO:0000269|PubMed:18625844}
Citations (0)

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Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity (By similarity).


Zheng, D., et al. J. Cell Biol. 182(1):89-101(2008)
Siddiqui, N., et al. J. Biol. Chem. 282(34):25067-25075(2007)
Nishimura, M., et al. DNA Res. 11(5):315-323(2004)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Hansen, J., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9918-9922(2003)

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$ 295.00
$ 99.00
Cat# AP13932b
(40 western blots)
Availability: In Stock
Bulk Size
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