|Application ||WB, E|
|Calculated MW||85378 Da|
|Antigen Region||71-100 aa|
|Other Names||Amiloride-sensitive amine oxidase [copper-containing], DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, AOC1, ABP1, DAO1|
|Target/Specificity||This ABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human ABP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Placenta and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a membrane glycoprotein that is expressed in many epithelium-rich and/or hematopoietic tissues and oxidatively deaminates putrescine and histamine. The protein may play a role in controlling the level of histamine and/or putrescine in these tissues. It also binds to and is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
McGrath, A.P., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 2), 137-142 (2010) :
Chambers, J.C., et al. Nat. Genet. 42(2):149-152(2010)
McGrath, A.P., et al. Biochemistry 48(41):9810-9822(2009)
Song, W.B., et al. World J. Gastroenterol. 15(31):3916-3919(2009)
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