|Application ||WB, E|
|Calculated MW||39474 Da|
|Antigen Region||259-287 aa|
|Other Names||D-amino-acid oxidase, DAAO, DAMOX, DAO, DAO, DAMOX|
|Target/Specificity||This DAO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the Central region of human DAO.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DAO Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
Kim, B., et al. Psychiatry Res 179(2):121-125(2010)
Caldinelli, L., et al. Protein Sci. 19(8):1500-1512(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Ohnuma, T., et al. Schizophr. Res. 118 (1-3), 300-302 (2010) :
Mitchell, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7556-7561(2010)
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