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LYPL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q5VWZ2 |
| Other Accession | NP_620149.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26316 Da |
| Antigen Region | 88-117 aa |
| Gene ID | 127018 |
|---|---|
| Other Names | Lysophospholipase-like protein 1, 312-, LYPLAL1 |
| Target/Specificity | This LYPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human LYPL1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LYPL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LYPLAL1 {ECO:0000303|PubMed:37802025, ECO:0000312|HGNC:HGNC:20440} |
|---|---|
| Function | Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 (PubMed:22052940, PubMed:22399288, PubMed:37802025). Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed:37802025). Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (PubMed:22052940). |
| Cellular Location | [Isoform 1]: Cytoplasm, cytosol |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The exact function of this protein remains unknown.
References
Hotta, K., et al. J. Hum. Genet. (2010) In press :
Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009) :
David, D., et al. Genomics 81(5):489-503(2003)
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