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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   SPATA18 Antibody (N-term)   

SPATA18 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPATA18 Antibody (N-term) AP13960A
    SPATA18 Antibody (N-term) (Cat. #AP13960a) western blot analysis in NCI-H292 cell line lysates (15ug/lane).This demonstrates the SPATA18 antibody detected SPATA18 protein (arrow).
  • WB - SPATA18 Antibody (N-term) AP13960A
    SPATA18 Antibody (N-term) (Cat. #AP13960a) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the SPATA18 antibody detected SPATA18 protein (arrow).
  • IHC-P - SPATA18 Antibody (N-term) AP13960A
    SPATA18 Antibody (N-term) (Cat. #AP13960a)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SPATA18 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TC71
Other Accession NP_660306.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61109 Da
Antigen Region 92-120 aa
Additional Information
Gene ID 132671
Other Names Mitochondria-eating protein, Spermatogenesis-associated protein 18, SPATA18, MIEAP
Target/Specificity This SPATA18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the N-terminal region of human SPATA18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPATA18 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPATA18
Synonyms MIEAP
Function Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
Cellular Location Cytoplasm. Mitochondrion outer membrane Note=Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033)
Research Areas
Citations ( 0 )


Potential role in spermatogenesis, especially in cell differentiation from late elongate spematids to mature spermatozoa (By similarity).


Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)
Kaindl, A.M., et al. Hum. Mutat. 26(3):279-280(2005)

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$ 295.00
$ 99.00
Cat# AP13960A
(40 western blots)
Availability: In Stock
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