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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PLSCR4 Antibody (Center)   

PLSCR4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PLSCR4 Antibody (Center) AP13974c
    PLSCR4 Antibody (Center) (Cat. #AP13974c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the PLSCR4 antibody detected the PLSCR4 protein (arrow).
  • IHC-P - PLSCR4 Antibody (Center) AP13974c
    PLSCR4 Antibody (Center) (Cat. #AP13974c)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PLSCR4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NRQ2
Other Accession NP_065086.2, NP_001121778.1, NP_001170775.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37005 Da
Antigen Region 122-151 aa
Additional Information
Gene ID 57088
Other Names Phospholipid scramblase 4, PL scramblase 4, Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, TRA1, PLSCR4
Target/Specificity This PLSCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the Central region of human PLSCR4.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPLSCR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLSCR4
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes
Research Areas
Citations (0)

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Background

PLSCR4 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sahu, S.K., et al. Biochim. Biophys. Acta 1790(10):1274-1281(2009)
Py, B., et al. PLoS ONE 4 (3), E5006 (2009) :
Shibata, H., et al. J. Biol. Chem. 283(15):9623-9632(2008)
Wiedmer, T., et al. Biochim. Biophys. Acta 1467(1):244-253(2000)

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Cat# AP13974c
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(40 western blots)
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