|Application ||WB, IHC-P, E|
|Other Accession||NP_065086.2, NP_001121778.1, NP_001170775.1|
|Calculated MW||37005 Da|
|Antigen Region||122-151 aa|
|Other Names||Phospholipid scramblase 4, PL scramblase 4, Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, TRA1, PLSCR4|
|Target/Specificity||This PLSCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the Central region of human PLSCR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLSCR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
PLSCR4 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sahu, S.K., et al. Biochim. Biophys. Acta 1790(10):1274-1281(2009)
Py, B., et al. PLoS ONE 4 (3), E5006 (2009) :
Shibata, H., et al. J. Biol. Chem. 283(15):9623-9632(2008)
Wiedmer, T., et al. Biochim. Biophys. Acta 1467(1):244-253(2000)
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