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PPCDC Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96CD2 |
| Other Accession | NP_068595.3 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22395 Da |
| Antigen Region | 37-66 aa |
| Gene ID | 60490 |
|---|---|
| Other Names | Phosphopantothenoylcysteine decarboxylase, PPC-DC, CoaC, PPCDC, COAC |
| Target/Specificity | This PPCDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human PPCDC. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPCDC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPCDC |
|---|---|
| Synonyms | COAC |
| Function | Catalyzes the decarboxylation of the cysteine moiety of 4- phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).
References
Strauss, E., et al. Biochemistry 43(49):15520-15533(2004)
Manoj, N., et al. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 10), 1762-1766 (2003) :
Daugherty, M., et al. J. Biol. Chem. 277(24):21431-21439(2002)
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