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LRRC8B Antibody (N-term )

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LRRC8B Antibody (N-term ) AP13978a
    LRRC8B Antibody (N-term ) (Cat. #AP13978a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the LRRC8B antibody detected the LRRC8B protein (arrow).
  • IHC-P - LRRC8B Antibody (N-term ) AP13978a
    LRRC8B Antibody (N-term ) (Cat. #AP13978a)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LRRC8B Antibody (N-term ) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6P9F7
Other Accession NP_001127948.1, NP_056165.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 92390 Da
Antigen Region 223-252 aa
Additional Information
Gene ID 23507
Other Names Volume-regulated anion channel subunit LRRC8B, Leucine-rich repeat-containing protein 8B, T-cell activation leucine repeat-rich protein, TA-LRRP, LRRC8B, KIAA0231
Target/Specificity This LRRC8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the N-terminal region of human LRRC8B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRRC8B Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0231
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8B constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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The exact function of LRRC8B remains unknown.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kubota, K., et al. FEBS Lett. 564 (1-2), 147-152 (2004) :
Robertson, N.G., et al. Genomics 23(1):42-50(1994)

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Cat# AP13978a
(40 western blots)
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