|Application ||WB, IHC-P, E|
|Other Accession||NP_001127948.1, NP_056165.1|
|Calculated MW||92390 Da|
|Antigen Region||223-252 aa|
|Other Names||Volume-regulated anion channel subunit LRRC8B, Leucine-rich repeat-containing protein 8B, T-cell activation leucine repeat-rich protein, TA-LRRP, LRRC8B, KIAA0231|
|Target/Specificity||This LRRC8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the N-terminal region of human LRRC8B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRRC8B Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
The exact function of LRRC8B remains unknown.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kubota, K., et al. FEBS Lett. 564 (1-2), 147-152 (2004) :
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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