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UNC45B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UNC45B Antibody (N-term) AP13982a
    UNC45B Antibody (N-term) (Cat. #AP13982a) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the UNC45B antibody detected the UNC45B protein (arrow).
    detail
  • IHC-P - UNC45B Antibody (N-term) AP13982a
    UNC45B Antibody (N-term) (Cat. #AP13982a)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UNC45B Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8IWX7
Other Accession Q8CGY6, NP_001028748.1, NP_775259.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 103733 Da
Antigen Region 235-264 aa
Additional Information
Gene ID 146862
Other Names Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45
Target/Specificity This UNC45B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the N-terminal region of human UNC45B.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUNC45B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC45B (HGNC:14304)
Synonyms CMYA4, UNC45
Function Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.
Cellular Location Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage {ECO:0000250|UniProtKB:Q6DGE9}
Tissue Location Expressed in eye lens tissues. Expressed in muscle (at protein level) (PubMed:33217308).
Research Areas
Citations (0)
citation

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Background

UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 [PubMed 12356907]).[supplied by OMIM].

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Price, M.G., et al. J. Cell. Sci. 115 (PT 21), 4013-4023 (2002) :

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$ 365.00
$ 140.00
Cat# AP13982a
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