UNC45B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q8IWX7 |
Other Accession | Q8CGY6, NP_001028748.1, NP_775259.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 103733 Da |
Antigen Region | 235-264 aa |
Gene ID | 146862 |
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Other Names | Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45 |
Target/Specificity | This UNC45B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the N-terminal region of human UNC45B. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UNC45B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UNC45B (HGNC:14304) |
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Synonyms | CMYA4, UNC45 |
Function | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. |
Cellular Location | Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage {ECO:0000250|UniProtKB:Q6DGE9} |
Tissue Location | Expressed in eye lens tissues. Expressed in muscle (at protein level) (PubMed:33217308). |
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Provided below are standard protocols that you may find useful for product applications.
Background
UNC45B plays a role in myoblast fusion and sarcomere organization (Price et al., 2002 [PubMed 12356907]).[supplied by OMIM].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Price, M.G., et al. J. Cell. Sci. 115 (PT 21), 4013-4023 (2002) :
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