|Application ||WB, E|
|Other Accession||NP_003992.3, NP_001002273.1, NP_001177757.1, NP_001002274.1|
|Calculated MW||34044 Da|
|Antigen Region||250-279 aa|
|Other Names||Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, CD32, FCGR2B, CD32, FCG2, IGFR2|
|Target/Specificity||This FCGR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human FCGR2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCGR2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD32, FCG2, IGFR2|
|Function||Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Prokopec, K.E., et al. Clin. Immunol. 137(3):322-329(2010)
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)
Niederer, H.A., et al. Hum. Mol. Genet. 19(16):3282-3294(2010)
Guilabert, A., et al. J. Am. Acad. Dermatol. 63(1):161-163(2010)
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