|Application ||WB, IHC-P, E|
|Calculated MW||66653 Da|
|Antigen Region||432-460 aa|
|Other Names||Matrix metalloproteinase-17, MMP-17, 3424-, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP, MMP17, MT4MMP|
|Target/Specificity||This MMP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-460 amino acids from the C-terminal region of human MMP17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.|
|Cellular Location||Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Huang, C.H., et al. Neoplasia 11(12):1371-1382(2009)
Atkinson, S.J., et al. Biochem. J. 398(1):15-22(2006)
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