|Application ||WB, IHC-P, E|
|Other Accession||NP_006564.1, NP_001139117.1|
|Calculated MW||31223 Da|
|Antigen Region||16-44 aa|
|Other Names||Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Target/Specificity||This TNFSF13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-44 amino acids from the N-terminal region of human TNFSF13B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNFSF13B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Function||Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
Zhang, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18956-18960(2010)
Molica, S., et al. Eur. J. Haematol. 85(4):314-320(2010)
Liu, J.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(3):690-693(2010)
Onda, K., et al. Int. J. Hematol. 91(5):808-819(2010)
Hayashi, E.A., et al. J. Immunol. 184(9):4662-4672(2010)
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