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NLRP12 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NLRP12 Antibody (N-term) AP14014a
    NLRP12 Antibody (N-term) (Cat. #AP14014a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP12 antibody detected the NLRP12 protein (arrow).
  • IHC-P - NLRP12 Antibody (N-term) AP14014a
    NLRP12 Antibody (N-term) (AP14014a)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NLRP12 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P59046
Other Accession NP_653288.1, NP_150639.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 120173 Da
Antigen Region 183-212 aa
Additional Information
Gene ID 91662
Other Names NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
Target/Specificity This NLRP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the N-terminal region of human NLRP12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNLRP12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP12
Synonyms NALP12, PYPAF7, RNO
Function May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Cellular Location Cytoplasm.
Tissue Location Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Research Areas
Citations ( 0 )


This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.


Bailey, S.D., et al. Diabetes Care (2010) In press :
Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008)
Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)

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$ 295.00
$ 99.00
Cat# AP14014a
(40 western blots)
Availability: In Stock
Bulk Size
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