BRD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | O95696 |
Other Accession | NP_055392.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 119520 Da |
Antigen Region | 73-102 aa |
Gene ID | 23774 |
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Other Names | Bromodomain-containing protein 1, BR140-like protein, Bromodomain and PHD finger-containing protein 2, BRD1, BRL, BRPF2 |
Target/Specificity | This BRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human BRD1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BRD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BRD1 {ECO:0000303|PubMed:16387653, ECO:0000312|HGNC:HGNC:1102} |
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Function | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). |
Cellular Location | Nucleus. Chromosome Note=Localizes to transcription start sites |
Tissue Location | Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kushima, I., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (3), 786-791 (2010) :
Nyegaard, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 582-591 (2010) :
Bjarkam, C.R., et al. Brain Struct Funct 214(1):37-47(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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