- CITATIONS: 1
|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||Q63149, P39038|
|Calculated MW||100281 Da|
|Antigen Region||175-203 aa|
|Other Names||Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4|
|Target/Specificity||This CDH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 amino acids from the N-terminal region of human CDH4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed mainly in brain but also found in other tissues|
Provided below are standard protocols that you may find useful for product applications.
CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Miotto,E., Cancer Res. 64 (22), 8156-8159 (2004)
Johnson,E., J. Biol. Chem. 279 (30), 31041-31049 (2004)
Kitagawa,M., Biochem. Biophys. Res. Commun. 271 (2), 358-363 (2000)
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