|Application ||WB, E|
|Other Accession||Q04666, P35428, Q3ZBG4, NP_005515.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||29541 Da|
|Antigen Region||3-32 aa|
|Other Names||Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY|
|Target/Specificity||This HES1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human HES1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HES1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB39, HL, HRY|
|Function||Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.|
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Provided below are standard protocols that you may find useful for product applications.
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Espinosa, L., et al. Cancer Cell 18(3):268-281(2010)
Wang, X., et al. J. Cancer Res. Clin. Oncol. 136(7):989-996(2010)
Sang, L., et al. Trends Mol Med 16(1):17-26(2010)
Duan, L., et al. Front Biosci (Elite Ed) 2, 1065-1072 (2010) :
Coad, R.A., et al. Biochem. Cell Biol. 87(6):975-987(2009)
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