|Application ||WB, E|
|Other Accession||P26044, Q9PU45, Q32LP2, NP_002897.1|
|Predicted||Bovine, Chicken, Pig|
|Calculated MW||68564 Da|
|Antigen Region||466-495 aa|
|Other Names||Radixin, RDX|
|Target/Specificity||This RDX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-495 amino acids from the C-terminal region of human RDX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RDX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively|
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Provided below are standard protocols that you may find useful for product applications.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.
Gloerich, M., et al. Mol. Cell. Biol. 30(22):5421-5431(2010)
Kramer, B., et al. Eur. J. Immunol. 39(12):3447-3458(2009)
Parisiadou, L., et al. J. Neurosci. 29(44):13971-13980(2009)
Belkina, N.V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(12):4707-4712(2009)
Wolf, C., et al. BMC Med. Genet. 10, 91 (2009) :
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