|Application ||WB, E|
|Other Accession||NP_001092884.1, NP_036338.2, NP_001166864.1|
|Calculated MW||38720 Da|
|Antigen Region||53-82 aa|
|Other Names||Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T-cell immunoglobulin mucin receptor 1, TIM, TIM-1, T-cell membrane protein 1, HAVCR1, KIM1, TIM1, TIMD1|
|Target/Specificity||This HAVCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human HAVCR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAVCR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIM1, TIM1, TIMD1|
|Function||May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)
Garcia-Lozano, J.R., et al. Hum. Genet. 128(2):221-229(2010)
Wichukchinda, N., et al. AIDS 24(11):1625-1631(2010)
Huo, W., et al. Transplant Rev (Orlando) 24(3):143-146(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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