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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NPPC Antibody (C-term)   

NPPC Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NPPC Antibody (C-term) AP14031b
    NPPC Antibody (C-term) (Cat. #AP14031b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NPPC antibody detected the NPPC protein (arrow).
  • IHC-P - NPPC Antibody (C-term) AP14031b
    NPPC Antibody (C-term) (AP14031b)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NPPC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P23582
Other Accession NP_077720.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 13246 Da
Antigen Region 80-109 aa
Additional Information
Gene ID 4880
Other Names C-type natriuretic peptide, CNP-22, CNP-29, CNP-53, NPPC, CNP2
Target/Specificity This NPPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the C-terminal region of human NPPC.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNPPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPPC
Synonyms CNP2
Function Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.

References

Lippert, S.K., et al. J. Immunol. Methods 362 (1-2), 32-37 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)
Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :

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Cat# AP14031b
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(40 western blots)
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