|Application ||WB, IHC-P, E|
|Calculated MW||13246 Da|
|Antigen Region||80-109 aa|
|Other Names||C-type natriuretic peptide, CNP-22, CNP-29, CNP-53, NPPC, CNP2|
|Target/Specificity||This NPPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the C-terminal region of human NPPC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.
Lippert, S.K., et al. J. Immunol. Methods 362 (1-2), 32-37 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)
Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :
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