|Application ||WB, E|
|Other Accession||NP_848701.1, NP_848702.1, NP_002710.2|
|Calculated MW||61061 Da|
|Antigen Region||465-494 aa|
|Other Names||Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2R5C, KIAA0044|
|Target/Specificity||This PPP2R5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human PPP2R5C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP2R5C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.|
|Cellular Location||Nucleus. Chromosome, centromere.|
|Tissue Location||Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)
Lee, T.Y., et al. J. Biol. Chem. 285(28):21567-21580(2010)
Shouse, G.P., et al. Oncogene 29(27):3933-3941(2010)
Tung, H.Y., et al. FEBS Lett. 401 (2-3), 197-201 (1997) :
McCright, B., et al. J. Biol. Chem. 271(36):22081-22089(1996)
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