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CUGBP1 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14036a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14036a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
CUGBP1 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q92879 |
| Other Accession | Q4QQT3, P28659, Q5F3T7, NP_001166110.1, NP_001020767.1, NP_941989.1, NP_001166111.1 |
| Reactivity | Human |
| Predicted | Chicken, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 52063 Da |
CUGBP1 Antibody (N-term) - Additional info | |
| Gene ID 10658 | |
| Other Names CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; Deadenylation factor CUG-BP; Embryo deadenylation element-binding protein homolog; RNA-binding protein BRUNOL-2 | |
| Target/Specificity This CUGBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CUGBP1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CUGBP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CUGBP1 Antibody (N-term) - Protein Information | |
| Name CELF1 | |
| Synonyms BRUNOL2, CUGBP, CUGBP1, NAB50 | |
| Function RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver | |
| Cellular Location Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments | |
| Tissue Location Ubiquitous. | |
CUGBP1 Antibody (N-term) - Related products
CUGBP1 Antibody (N-term) - Application data
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CUGBP1 Antibody (N-term) (Cat. #AP14036a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CUGBP1 antibody detected the CUGBP1 protein (arrow).
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CUGBP1 Antibody (N-term) (AP14036a)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CUGBP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
CUGBP1 Antibody (N-term) - Research Areas
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BACKGROUND
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
REFERENCES
Rattenbacher, B., et al. Mol. Cell. Biol. 30(16):3970-3980(2010) Le Tonqueze, O., et al. Biochem. Biophys. Res. Commun. 394(4):884-889(2010) Koshelev, M., et al. Hum. Mol. Genet. 19(6):1066-1075(2010) Tsuda, K., et al. Nucleic Acids Res. 37(15):5151-5166(2009) Bubenik, J.L., et al. RNA Biol 6(1):73-83(2009)
