|Application ||WB, E|
|Other Accession||P28646, P30873, NP_001040.1|
|Calculated MW||42686 Da|
|Antigen Region||351-380 aa|
|Other Names||Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2, SSTR1|
|Target/Specificity||This SSTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human SSTR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SSTR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach|
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Provided below are standard protocols that you may find useful for product applications.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. [provided by RefSeq].
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Pisarek, H., et al. Folia Histochem. Cytobiol. 48(1):142-147(2010)
Johansson, M., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1644-1650(2009)
Casarini, A.P., et al. Pituitary 12(4):297-303(2009)
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