|Application ||WB, IHC-P, E|
|Calculated MW||54014 Da|
|Antigen Region||362-391 aa|
|Other Names||Hematopoietic lineage cell-specific protein, Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HCLS1, HS1|
|Target/Specificity||This HCLS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 362-391 amino acids from the C-terminal region of human HCLS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HCLS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.|
|Cellular Location||Membrane; Peripheral membrane protein Cytoplasm. Mitochondrion|
|Tissue Location||Expressed only in tissues and cells of hematopoietic origin|
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Provided below are standard protocols that you may find useful for product applications.
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Muzio, M., et al. Leukemia 21(9):2067-2070(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
Hao, J.J., et al. J. Biol. Chem. 280(45):37988-37994(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Brunati, A.M., et al. J. Biol. Chem. 280(22):21029-21035(2005)
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