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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   STAM2 Antibody (Center)   

STAM2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - STAM2 Antibody (Center) AP14042c
    STAM2 Antibody (Center) (Cat. #AP14042c) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the STAM2 antibody detected the STAM2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75886
Other Accession NP_005834.4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58164 Da
Antigen Region 143-172 aa
Additional Information
Gene ID 10254
Other Names Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP
Target/Specificity This STAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human STAM2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTAM2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAM2
Synonyms HBP
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Cellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.


Stuible, M., et al. J. Biol. Chem. 285(31):23899-23907(2010)
Rismanchi, N., et al. Traffic 10(2):201-217(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Kong, C., et al. J. Biol. Chem. 282(20):15294-15301(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 295.00
$ 99.00
Cat# AP14042c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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