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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PCSK7 Antibody (C-term)   

PCSK7 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PCSK7 Antibody (C-term) AP14045B
    PCSK7 Antibody (C-term) (Cat. #AP14045b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PCSK7 antibody detected the PCSK7 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16549
Other Accession NP_004707.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86247 Da
Antigen Region 692-721 aa
Additional Information
Gene ID 9159
Other Names Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7
Target/Specificity This PCSK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human PCSK7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCSK7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCSK7
Synonyms LPC, PC7, PC8, SPC7
Function Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Seems to be localized intracellularly to the trans Golgi network.
Tissue Location Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.


Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010)
McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007)
Bruzzaniti, A., et al. Peptides 23(5):863-875(2002)
Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002)
Pearton, D.J., et al. Exp. Dermatol. 10(3):193-203(2001)

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$ 295.00
$ 99.00
Cat# AP14045B
(40 western blots)
Availability: In Stock
Bulk Size
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