|Application ||WB, E|
|Calculated MW||22405 Da|
|Antigen Region||46-75 aa|
|Other Names||Neurturin, NRTN|
|Target/Specificity||This NRTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human NRTN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NRTN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.|
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Provided below are standard protocols that you may find useful for product applications.
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq].
Fernandez, R.M., et al. J. Pediatr. Surg. 43(11):2042-2047(2008)
Adly, M.A., et al. J. Am. Acad. Dermatol. 58(2):238-250(2008)
Yoong, L.F., et al. J. Neurosci. 27(21):5603-5614(2007)
Yoong, L.F., et al. J. Neurochem. 98(4):1149-1158(2006)
Vargas-Leal, V., et al. J. Immunol. 175(4):2301-2308(2005)
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