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CIDEA Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CIDEA Antibody (C-term) AP14057b
    CIDEA Antibody (C-term) (Cat. #AP14057b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CIDEA antibody detected the CIDEA protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O60543
Other Accession NP_001270.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24687 Da
Antigen Region 181-209 aa
Additional Information
Gene ID 1149
Other Names Cell death activator CIDE-A, Cell death-inducing DFFA-like effector A, CIDEA
Target/Specificity This CIDEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human CIDEA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCIDEA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIDEA {ECO:0000303|PubMed:18509062, ECO:0000312|HGNC:HGNC:1976}
Function Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity).
Cellular Location Lipid droplet. Nucleus {ECO:0000250|UniProtKB:O70302}. Note=Enriched at lipid droplet contact sites.
Tissue Location Expressed in omental and subcutaneous adipose tissue (at protein level).
Research Areas
Citations (0)
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Background

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.

References

Li, F., et al. FEBS J. 277(20):4173-4183(2010)
Ito, M., et al. J. Lipid Res. 51(7):1676-1684(2010)
Huang, Y.W., et al. Gynecol. Oncol. 117(2):239-247(2010)
Laurencikiene, J., et al. Cancer Res. 68(22):9247-9254(2008)
Valouskova, E., et al. Gen. Physiol. Biophys. 27(2):92-100(2008)

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$ 182.50
$ 70.00
Cat# AP14057b
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