|Application ||WB, IHC-P, E|
|Other Accession||NP_002552.2, NP_778255.1, NP_778256.1|
|Calculated MW||47205 Da|
|Antigen Region||325-353 aa|
|Other Names||P2X purinoceptor 5, P2X5, ATP receptor, Purinergic receptor, P2RX5, P2X5|
|Target/Specificity||This P2RX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-353 amino acids from the C-terminal region of human P2RX5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP that acts as a ligand-gated ion channel.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at high levels in brain and immune system|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.
Kotnis, S., et al. Mol. Pharmacol. 77(6):953-960(2010)
Overes, I.M., et al. Cancer Immunol. Immunother. 58(3):429-439(2009)
Dubyak, G.R. Mol. Pharmacol. 72(6):1402-1405(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Duckwitz, W., et al. J. Biol. Chem. 281(51):39561-39572(2006)
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