|Application ||WB, E|
|Calculated MW||42900 Da|
|Antigen Region||138-167 aa|
|Other Names||Synaptotagmin-5, Synaptotagmin V, SytV, SYT5|
|Target/Specificity||This SYT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human SYT5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYT5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment.|
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Provided below are standard protocols that you may find useful for product applications.
SYT5 may be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :
Sreenath, A.S., et al. Clin. Biochem. 38(5):436-443(2005)
Mizutani, A., et al. J. Biol. Chem. 275(13):9823-9831(2000)
Craxton, M., et al. FEBS Lett. 460(3):417-422(1999)
Fukuda, M., et al. J. Biol. Chem. 274(44):31421-31427(1999)
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