|Application ||WB, E|
|Calculated MW||83418 Da|
|Antigen Region||200-228 aa|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC|
|Target/Specificity||This ADAM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the N-terminal region of human ADAM11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAM11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed predominantly in brain. Slightly detected or not at all in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq].
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Shea, S.H., et al. Behav. Genet. 31(2):231-239(2001)
Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :
Wolfsberg, T.G., et al. J. Cell Biol. 131(2):275-278(1995)
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