|Application ||WB, IHC-P, E|
|Other Accession||Q32LE9, NP_001312.1|
|Calculated MW||20954 Da|
|Antigen Region||68-96 aa|
|Other Names||Cysteine and glycine-rich protein 2, Cysteine-rich protein 2, CRP2, LIM domain only protein 5, LMO-5, Smooth muscle cell LIM protein, SmLIM, CSRP2, LMO5, SMLIM|
|Target/Specificity||This CSRP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the Central region of human CSRP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSRP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.|
|Tissue Location||Highly expressed in the aorta, but not in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.
Stearns, M.E., et al. Mol. Cancer Res. 1(9):631-642(2003)
Wang, M., et al. Cancer Biol. Ther. 1(5):556-563(2002)
Weiskirchen, R., et al. Biochem. J. 359 (PT 3), 485-496 (2001) :
Weiskirchen, R., et al. Biochem. Biophys. Res. Commun. 274(3):655-663(2000)
Weiskirchen, R., et al. Genomics 44(1):83-93(1997)
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