|Application ||WB, IHC-P, E|
|Calculated MW||119109 Da|
|Antigen Region||198-226 aa|
|Other Names||Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, ANP-A, ANPR-A, NPR-A, Guanylate cyclase A, GC-A, Npr1, Npra|
|Target/Specificity||This Mouse Npr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the N-terminal region of mouse Npr1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Npr1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Madhani, M., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (3), H827-H836 (2010) :
Panayiotou, C.M., et al. Br. J. Pharmacol. 160(8):2045-2054(2010)
Ropero, A.B., et al. Endocrinology 151(8):3665-3674(2010)
Tankersley, C.G., et al. Inhal Toxicol 22(8):695-707(2010)
Long, L., et al. Neuro Endocrinol. Lett. 31(1):126-130(2010)
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