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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Plk2 Antibody (Center)   

Mouse Plk2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Plk2 Antibody (Center) AP14082C
    Mouse Plk2 Antibody (Center) (Cat. #AP14082c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the Plk2 antibody detected the Plk2 protein (arrow).
  • WB - Mouse Plk2 Antibody (Center) AP14082C
    Mouse Plk2 Antibody (Center) (Cat. #AP14082c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Plk2 antibody detected the Plk2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P53351
Other Accession Q9R012, NP_690017.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 77812 Da
Antigen Region 354-382 aa
Additional Information
Gene ID 20620
Other Names Serine/threonine-protein kinase PLK2, Polo-like kinase 2, PLK-2, Serine/threonine-protein kinase SNK, Serum-inducible kinase, Plk2, Snk
Target/Specificity This Mouse Plk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the Central region of mouse Plk2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Plk2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Plk2
Synonyms Snk
Function Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, dendrite. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
Tissue Location Brain, lung and heart.
Research Areas
Citations (0)

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Plk2 may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia.


Hutchins, J.R., et al. Science 328(5978):593-599(2010)
Inglis, K.J., et al. J. Biol. Chem. 284(5):2598-2602(2009)
Park, Y.Y., et al. Biochem. Biophys. Res. Commun. 362(1):107-113(2007)
Nishimura, M., et al. DNA Res. 11(5):315-323(2004)
Ma, S., et al. Mol. Cell. Biol. 23(19):6936-6943(2003)

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Cat# AP14082C
(40 western blots)
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