|Application ||WB, IHC-P, E|
|Calculated MW||66116 Da|
|Antigen Region||535-564 aa|
|Other Names||Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS, FARSB, FARSLB, FRSB|
|Target/Specificity||This FARSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-564 amino acids from the C-terminal region of human FARSB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FARSB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Finarov, I., et al. Structure 18(3):343-353(2010)
Yu, X.Y., et al. Bioorg. Med. Chem. Lett. 14(5):1339-1342(2004)
Vasil'eva, I.A., et al. Biochemistry Mosc. 69(2):143-153(2004)
Moor, N., et al. Biochemistry 42(36):10697-10708(2003)
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