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SLC38A5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WUX1 |
| Other Accession | NP_277053.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51457 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 92745 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 5, Solute carrier family 38 member 5, System N transporter 2, SLC38A5, JM24, SN2, SNAT5 |
| Target/Specificity | This SLC38A5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC38A5. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC38A5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A5 |
|---|---|
| Synonyms | JM24, SN2 {ECO:0000303|PubMed:11243884}, |
| Function | Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate- glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:A2VCW5}; Multi-pass membrane protein. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5} |
| Tissue Location | Predominantly expressed in stomach, brain, liver, lung and intestinal tract. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a system N sodium-coupled amino acid transporter involved in the transfer of glutamine, asparagine, histidine, serine, alanine, and glycine. The encoded protein does not transport charged amino acids, imino acids, or N-alkylated amino acids. This transporter is not inhibited by lithium.
References
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Froyen, G., et al. Hum. Genet. 121(5):539-547(2007)
Nakanishi, T., et al. Biochem. Biophys. Res. Commun. 281(5):1343-1348(2001)
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