|Application ||WB, IHC-P, E|
|Other Accession||P25801, NP_001135788.1, NP_001135787.1, NP_005565.2|
|Calculated MW||18358 Da|
|Antigen Region||1-30 aa|
|Other Names||Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2, LMO2, RBTN2, RBTNL1, RHOM2, TTG2|
|Target/Specificity||This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LMO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LMO2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RBTN2, RBTNL1, RHOM2, TTG2|
|Function||Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.|
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Provided below are standard protocols that you may find useful for product applications.
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
Oram, S.H., et al. Oncogene 29(43):5796-5808(2010)
Younes, S.F., et al. Am. J. Surg. Pathol. 34(9):1266-1276(2010)
Hirose, K., et al. Blood 116(6):962-970(2010)
Durnick, D.K., et al. Am. J. Clin. Pathol. 134(2):278-281(2010)
Cobanoglu, U., et al. Hematology 15(3):132-134(2010)
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