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LMO2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LMO2 Antibody (N-term) AP14102a
    LMO2 Antibody (N-term) (Cat. #AP14102a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the LMO2 antibody detected the LMO2 protein (arrow).
    detail
  • IHC-P - LMO2 Antibody (N-term) AP14102a
    LMO2 Antibody (N-term) (Cat. #AP14102a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LMO2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P25791
Other Accession P25801, NP_001135788.1, NP_001135787.1, NP_005565.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 18358 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 4005
Other Names Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2, LMO2, RBTN2, RBTNL1, RHOM2, TTG2
Target/Specificity This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LMO2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLMO2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMO2
Synonyms RBTN2, RBTNL1, RHOM2, TTG2
Function Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

References

Oram, S.H., et al. Oncogene 29(43):5796-5808(2010)
Younes, S.F., et al. Am. J. Surg. Pathol. 34(9):1266-1276(2010)
Hirose, K., et al. Blood 116(6):962-970(2010)
Durnick, D.K., et al. Am. J. Clin. Pathol. 134(2):278-281(2010)
Cobanoglu, U., et al. Hematology 15(3):132-134(2010)

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$ 182.50
$ 70.00
Cat# AP14102a
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